Request for EoE Study Referrals


Eosinophilic Esophagitis (EoE) dupilumab trial(R668-EE-1774)

KEY POINTS

Contact Study Coordinator: Jessica Barlas jessbarlas@nyallergy.com or call 212-686-6321

DBPC study of adolescent and adults with EoE x 6 months followed by open label dupilumab treatment x 6 months. Principal investigator: Robert Y Lin MD, Co-investigators Hon-Ming Eng MD & Morris Nejat MD

Key inclusion criteria:

       History of Dysphagia: An average of at least 2 episodes of dysphagia per week in the 4 weeks prior to screening.

*         EoE endoscopically diagnosed (>15/HPF) any time in the past after 8 weeks high-dose PPI treatment(eg omeprazole 40 mg/d or equivalent).

*         Biopsy could have been within 2 weeks of 8 week PPI treatment course if stopped.

Key exclusion criteria:

*         Swallowed steroid treatment in the prior 8 weeks

*         Any prior dupilumab

*         Use of immunomodulatory/biologic drugs in the prior 3 months

*         Any serious systemic, malignant or other serious GI diseases

*         Changed inhaled or nasal steroids or leukotriene modifier drugs or allergy shots in the prior 8 weeks (can be on stable doses).

Intervention: weekly injections of dupilumab or placebo.  Patients will be screened for requisite dysphagia frequency and baseline endoscopy showing EoE before randomization.

Evaluations: baseline & interval labs/questionnaires, endoscopy at screening, 6 m and 12 m, visits every 1-4 weeks(more in the beginning less at the end)

Reimbursements: ~$50 per visit, endoscopy visits ~$250


Rockefeller University is seeking individuals with hereditary angioedema (HAE)


The Rockefeller University is seeking individuals with hereditary angioedema (HAE) to participate in a clinical research study. Researchers are assessing the activation of the "contact system" proteins found in the blood of individuals with HAE. Those who are currently participating in a drug-sponsored clinical trials are also considered. For more information, please refer to our study advertisement or for more details, click this linkYou can also email the principal investigator Dr. Tukisa Smith tsmith@rockefeller.edu regarding further questions




Updated 9/10/2019

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